Every time someone gives one of those “how wounds heal” lectures, it starts with “the first phase of wound healing is hemostasis,” and we think to ourselves, “Yeah, yeah, everybody knows that part . . .” Lately I’ve been paying more attention to the issue of hemostasis, or perhaps the lack of it. The US Wound Registry collects observations on the character of wound drainage as a structured field and the concept “bloody” was not used very often until a few years ago. Now it seems like a lot more patients have bloody drainage. I’m noticing this in my patients. They ooze blood even under their compression wraps. It’s not that they bleed because their dressings got stuck. You can see that the blood has been gradually oozing for days.
Out of curiosity, we looked at US Wound Registry (USWR) data to see what percentage of chronic wound patients were on anticoagulants or anti-platelet therapy (excluding aspirin). We only analyzed patients with wounds and ulcers from January 1, 2017 to November 27, 2018. There were 19,471 total patients of whom 9,700 were on an anticoagulant or blood thinner (19% of the total) with the distribution being: Plavix 6.9%, Coumadin 6.2%, Eliquis 3.8%, Xeralto 2.8%, Pletal 0.7%, and Pradaxa 0.5%.
Based on USWR data (at least since 2017), 19% of all patients with chronic wounds and ulcers are on anticoagulants or antiplatelet agents. I can tell you that the majority of patients taking anticoagulants have atrial fibrillation, although some have a history of deep venous thrombosis.
I can also tell you that I see a lot of bloody dressings. And lately, when I see dressings that stay bloody and wounds that aren’t making progress, I’ve starting putting products like Quick Clot into the wound bed.
Here’s a patient with atrial fibrillation and some really refractory venous ulcers. He had been getting recurrent ulcerations for 3 years (he also had CHF). This particular wound had not improved for 2 months. You can see that the wound dressings under the compression dressing had red-black ooze. The next photo is the wound about a week later and the dressing which still is pink but not as bloody, and then 8 weeks later when the wound is clearly healing. I think the primary difference was that I was putting Quick Clot on the wound to stop the oozing.

Has anyone else noticed this? We could figure out whether bleeding is an issue using USWR data, but it’s a “real world” problem and I don’t see anyone really wanting to know the answer to this, or whether there’s an association between slower healing and any of these medications.
Here’s a 9 second video of a patient on blood thinners whose granulation tissue just oozes. Yes, it’s true that granulation tissue is “friable” if it’s colonized but …uh… this is bleeding….
[vimeo 303280520 w=1080 h=1920]
Since the first phase of wound healing is hemostasis – I’m just observing that we may have a bleeding obvious problem.