Yes, more evidence that Vitamin D is good for you

A study by Arayici and colleagues just released in the journal “Nutrients”* summarizes the pooled analysis of numerous meta-analyses of serum 25(OH)D levels, vitamin D intake and cancer risk. The researchers found that higher 25(OH)D levels were linked to a lower risk of developing cancer (OR = 0.8; 95% CI, 0.72-0.89), and that higher serum 25(OH)D levels were associated with a 26% reduction in cancer mortality (RR = 0.74, 95% CI, 0.69-0.8). Vitamin D intake itself was linked to an 11% reduced mortality risk (RR = 0.89, 95% CI, 0.85-0.93). I can only assume that, due to significant variations between individuals in vitamin D metabolism, the intake of Vitamin D is less correlated with cancer development and outcome than actual serum serum 25(OH)D levels.

Nearly every one of my patients with a chronic wound says, “I take Vitamin D,” but as I’ve mentioned before, the current recommended daily dose of Vitamin D is probably far too low (due to an error in the way that the original studies were analyzed). In other words, most people just don’t take enough. I’ve also mentioned the fact that it can be hard to get insurance to pay for a 25(OH)D level (hint – insurance seems to accept a risk of failing as a reason for the test…)

I’ve blogged previously about the vital importance of Vitamin D for wound healing:

Nutritional Screening and Vitamin D Groundhog Day

Wound Whisperer: Shhhh… My Secret Vitamin D Treatment for a Surgical Wound Dehiscence

Don’t Miss This! The Vitamin D Deficiency Epidemic (…and yes, that is a pulsating Dorsalis Pedis artery)

COVID survival & the development of diabetes:

Daily “Higher Dose” Vitamin D May Help Delay Diabetes

…and now cancer risk, this insurance barrier is frankly ridiculous:

“You Are Liable For This Charge (For a Vitamin D Level)”

At any rate, Arayici and colleagues concluded that, “…vitamin D intake and high serum 25(OH)D levels can significantly reduce the incidence and mortality of various cancers.” So, I will keep ordering 25(OH)D levels, and fighting with insurance about covering it.

*Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies. Nutrients 2023, 15(12), 2722